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. 2003 Mar 28;299(5615):2071-4.
doi: 10.1126/science.1080613.

Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis

I T Paulsen  1 , L Banerjei, G S A Myers, K E Nelson, R Seshadri, T D Read, D E Fouts, J A Eisen, S R Gill, J F Heidelberg, H Tettelin, R J Dodson, L Umayam, L Brinkac, M Beanan, S Daugherty, R T DeBoy, S Durkin, J Kolonay, R Madupu, W Nelson, J Vamathevan, B Tran, J Upton, T Hansen, J Shetty, H Khouri, T Utterback, D Radune, K A Ketchum, B A Dougherty, C M Fraser
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Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus faecalis

I T Paulsen et al. Science. .

Abstract

The complete genome sequence of Enterococcus faecalis V583, a vancomycin-resistant clinical isolate, revealed that more than a quarter of the genome consists of probable mobile or foreign DNA. One of the predicted mobile elements is a previously unknown vanB vancomycin-resistance conjugative transposon. Three plasmids were identified, including two pheromone-sensing conjugative plasmids, one encoding a previously undescribed pheromone inhibitor. The apparent propensity for the incorporation of mobile elements probably contributed to the rapid acquisition and dissemination of drug resistance in the enterococci.

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