Degradation of mRNA in Escherichia coli
- PMID: 12665241
- DOI: 10.1080/15216540216036
Degradation of mRNA in Escherichia coli
Abstract
Degradation of messenger RNAs (mRNAs) is a universal process that occurs in every cell and has important implications for nucleotide metabolism and gene expression. One organism in which mRNA degradation has been thoroughly studied is the bacterium Escherichia coli (E. coli). In this review I describe what is presently known about the different processes involved in the conversion of mRNAs from high molecular weight species to mononucleotides in E. coli. The ribonucleases and accessory factors involved in mRNA degradation, and features on mRNAs that make them resistant or sensitive to degradation will also be described. At the conclusion of this review, some of the anticipated directions of future research on this topic will be discussed.
Similar articles
-
RNase E-based ribonucleoprotein complexes: mechanical basis of mRNA destabilization mediated by bacterial noncoding RNAs.Genes Dev. 2005 Sep 15;19(18):2176-86. doi: 10.1101/gad.1330405. Genes Dev. 2005. PMID: 16166379 Free PMC article.
-
Replication initiator protein mRNA of ColE2 plasmid and its antisense regulator RNA are under the control of different degradation pathways.Plasmid. 2008 Mar;59(2):102-10. doi: 10.1016/j.plasmid.2007.11.002. Epub 2008 Jan 11. Plasmid. 2008. PMID: 18191205
-
Mechanism of RNA silencing by Hfq-binding small RNAs.Curr Opin Microbiol. 2007 Apr;10(2):134-9. doi: 10.1016/j.mib.2007.03.010. Epub 2007 Mar 26. Curr Opin Microbiol. 2007. PMID: 17383928 Review.
-
Translation initiation and the fate of bacterial mRNAs.FEMS Microbiol Rev. 2006 Nov;30(6):967-79. doi: 10.1111/j.1574-6976.2006.00043.x. Epub 2006 Sep 21. FEMS Microbiol Rev. 2006. PMID: 16989654 Review.
-
RraA. a protein inhibitor of RNase E activity that globally modulates RNA abundance in E. coli.Cell. 2003 Sep 5;114(5):623-34. Cell. 2003. PMID: 13678585
Cited by
-
Mechanistically consistent reduced models of synthetic gene networks.Biophys J. 2013 May 7;104(9):2098-109. doi: 10.1016/j.bpj.2013.03.031. Biophys J. 2013. PMID: 23663853 Free PMC article.
-
Degradation of RNA in bacteria: comparison of mRNA and stable RNA.Nucleic Acids Res. 2006 Feb 1;34(2):659-66. doi: 10.1093/nar/gkj472. Print 2006. Nucleic Acids Res. 2006. PMID: 16452296 Free PMC article. Review.
-
Identification and analysis of Escherichia coli ribonuclease E dominant-negative mutants.Genetics. 2006 Jan;172(1):7-15. doi: 10.1534/genetics.105.048553. Epub 2005 Oct 3. Genetics. 2006. PMID: 16204212 Free PMC article.
-
A coarse-grained bacterial cell model for resource-aware analysis and design of synthetic gene circuits.Nat Commun. 2024 Mar 4;15(1):1981. doi: 10.1038/s41467-024-46410-9. Nat Commun. 2024. PMID: 38438391 Free PMC article.
-
Antimicrobial Activity and Mechanisms of Walnut Green Husk Extract.Molecules. 2023 Dec 7;28(24):7981. doi: 10.3390/molecules28247981. Molecules. 2023. PMID: 38138470 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources
