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. 2003 Apr;56(2):127-8.
doi: 10.1136/mp.56.2.127.

Proposal for a unified CCN nomenclature

D R Brigstock  1 , R Goldschmeding, K-i Katsube, S C-T Lam, L F Lau, K Lyons, C Naus, B Perbal, B Riser, M Takigawa, H Yeger
Affiliations

Proposal for a unified CCN nomenclature

D R Brigstock et al. Mol Pathol. 2003 Apr.

Abstract

A proposal is put forth to unify the nomenclature of the CCN family of secreted, cysteine rich regulatory proteins. In the order of their description in the literature, CCN1 (CYR61), CCN2 (CTGF), CCN3 (NOV), CCN4 (WISP-1), CCN5 (WISP-2), and CCN6 (WISP-3) constitute a family of matricellular proteins that regulate cell adhesion, migration, proliferation, survival, and differentiation, at least in part through integrin mediated mechanisms. This proposal is endorsed by the International CCN Society and will serve to eliminate confusion from the multiple names that have been given to these molecules.

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References

    1. Perbal B, Brigstock DR, Lau LF. Report on the second international workshop on the CCN family of genes. Mol Pathol 2003;56:80–85. - PMC - PubMed
    1. Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett 1993;327:125–30. - PubMed
    1. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev 1999;20:189–206. - PubMed
    1. Lau LF, Lam SC-T. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res 1999;248:44–57. - PubMed
    1. Perbal B. NOV (nephroblastoma overexpressed) and the CCN family of genes: structural and functional issues. Mol Pathol 2001;54:57–79. - PMC - PubMed

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