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Review
. 2003 Mar;11(3):557-69.
doi: 10.1016/s1097-2765(03)00103-5.

The making of the mitotic chromosome: modern insights into classical questions

Jason R Swedlow  1 , Tatsuya Hirano
Affiliations
Free article
Review

The making of the mitotic chromosome: modern insights into classical questions

Jason R Swedlow et al. Mol Cell. 2003 Mar.
Free article

Abstract

The condensation of mitotic chromosomes is essential for the faithful segregation of sister chromatids in anaphase. An emerging view is that chromosome assembly is an active and dynamic process of chromatin reorganization in which two ATP hydrolyzing enzymes, topoisomerase II and the condensin complex, play central roles. In this review, we discuss recent work that sheds new light on the molecular and structural dynamics of mitotic chromosomes.

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