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Review
. 2003 Apr;3(4):292-303.
doi: 10.1038/nri1054.

Organogenesis of lymphoid tissues

Reina E Mebius  1
Affiliations
Review

Organogenesis of lymphoid tissues

Reina E Mebius. Nat Rev Immunol. 2003 Apr.

Erratum in

  • Nat Rev Immunol. 2003 Jun;3(6):509

Abstract

The development of lymphoid organs depends on the correct expression of several molecules within a defined timeframe during ontogeny. Although this is an extremely complex process, with each secondary lymphoid tissue requiring subtly different signals, a common framework for lymphoid development is beginning to emerge. Drawing on studies of lymph nodes, Peyer's patches and nasal-associated lymphoid tissue, an integrative model of lymphoid-tissue development, involving adhesion molecules, cytokines and chemokines, which emphasizes the role of interactions between CD3-CD4+CD45+ 'inducer' cells and VCAM1+ICAM1+ stromal 'organizer' cells is presented.

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