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Comparative Study
. 2003 Apr;54(4):321-3.
doi: 10.1007/s00105-003-0513-6. Epub 2003 Mar 6.

[Follicular penetration. An important pathway for topically applied substances]

[Article in German]
J Lademann  1 , N Otberg, H Richter, U Jacobi, H Schaefer, U Blume-Peytavi, W Sterry
Affiliations
Comparative Study

[Follicular penetration. An important pathway for topically applied substances]

[Article in German]
J Lademann et al. Hautarzt. 2003 Apr.

Abstract

The knowledge of penetration pathways in and through the skin is a prerequisite for the development and optimization of topically applied drugs and cosmetics. Skin penetration has been assumed to occur via diffusion though the lipid domains of the stratum corneum. Recent studies show that the skin appendages, especially the hair follicles, play an important role in skin penetration processes. Topically applied substances cannot enter all follicles. We discuss the reasons for the phenomenon of open and closed hair follicles.

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References

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