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Review
. 2003 Apr;111(7):945-7.
doi: 10.1172/JCI18235.

The hunting of the snark: the elusive calcium receptor(s)

Lawrence G Raisz  1
Affiliations
Review

The hunting of the snark: the elusive calcium receptor(s)

Lawrence G Raisz. J Clin Invest. 2003 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Upon comparison with sex-matched control littermates (a) PTH–/–CaSR–/– mice exhibited parathyroid hyperplasia (b) (14). The enlargement of the parathyroid glands in PTH–/–CaSR–/– animals could indicate that CaSR plays an important regulatory role in limiting parathyroid size and cell replication.
Figure 2
Figure 2
Nondecalcified histologic sections of the tibia of 1-week-old (a) CasR-deficient, and (b) CasR- and Gcm2-deficient mice. Double knockout reverses the mineralization defect observed in CasR–/– mice. This result indicates that an excess of PTH may somehow directly produce a picture of rickets and osteomalacia and that this abnormality is not due to the absence of CaSR in bone cells. It will be important to find out what very high PTH levels might be doing to the proteins and transport systems that regulate mineralization in these mice.
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Comment on

References

    1. Brown EM. Extracellular Ca2+ sensing, regulation of parathyroid cell function, and role of Ca2+ and other ions as extracellular (first) messengers. Physiol. Rev. 1991;71:371–411. - PubMed
    1. Brown EM, et al. Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid. Nature. 1993;366:575–580. - PubMed
    1. Pollak MR, et al. Mutations in the human Ca(2+)-sensing receptor gene cause familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Cell. 1993;75:1297–1303. - PubMed
    1. Pollak MR, Seidman CE, Brown EM. Three inherited disorders of calcium sensing. Medicine. 1996;75:115–123. - PubMed
    1. Ho C, et al. A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism. Nat. Genet. 1995;11:389–394. - PubMed