Review
doi: 10.1038/nrc1045.
The power and the promise of DNA methylation markers
Affiliations
- PMID: 12671664
- DOI: 10.1038/nrc1045
Item in Clipboard
Review
The power and the promise of DNA methylation markers
Nat Rev Cancer.
2003 Apr.
Abstract
The past few years have seen an explosion of interest in the epigenetics of cancer. This has been a consequence of both the exciting coalescence of the chromatin and DNA methylation fields, and the realization that DNA methylation changes are involved in human malignancies. The ubiquity of DNA methylation changes has opened the way to a host of innovative diagnostic and therapeutic strategies. Recent advances attest to the great promise of DNA methylation markers as powerful future tools in the clinic.
Similar articles
-
Methods to detect circulating tumor DNA may help early diagnosis of cancer.JAMA. 2007 Nov 7;298(17):1993-4. doi: 10.1001/jama.298.17.1993. JAMA. 2007. PMID: 17986686 No abstract available.
-
Epigenetic diagnostics of cancer--the application of DNA methylation markers.J Appl Genet. 2006;47(4):365-75. doi: 10.1007/BF03194647. J Appl Genet. 2006. PMID: 17132902 Review.
-
[Applications of DNA methylation markers in forensic medicine].Fa Yi Xue Za Zhi. 2005 Feb;21(1):61-4. Fa Yi Xue Za Zhi. 2005. PMID: 15895811 Review. Chinese.
-
Analysis of genome-wide in cell free DNA methylation: progress and prospect.Analyst. 2019 Oct 7;144(20):5912-5922. doi: 10.1039/c9an00935c. Analyst. 2019. PMID: 31436778 Review.
-
DNA methylation signatures in circulating cell-free DNA as biomarkers for the early detection of cancer.Sci China Life Sci. 2017 Apr;60(4):356-362. doi: 10.1007/s11427-016-0253-7. Epub 2017 Jan 5. Sci China Life Sci. 2017. PMID: 28063009 Review.
Cited by
-
The epigenetic paradigm in periodontitis pathogenesis.J Indian Soc Periodontol. 2015 Mar-Apr;19(2):142-9. doi: 10.4103/0972-124X.145784. J Indian Soc Periodontol. 2015. PMID: 26015662 Free PMC article. Review.
-
Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology.Clin Epigenetics. 2016 Sep 13;8(1):96. doi: 10.1186/s13148-016-0263-9. eCollection 2016. Clin Epigenetics. 2016. PMID: 27651839 Free PMC article.
-
Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer.Genome Res. 2012 Feb;22(2):246-58. doi: 10.1101/gr.125872.111. Epub 2011 Dec 7. Genome Res. 2012. PMID: 22156296 Free PMC article.
-
DNA methylation in the human placenta and fetal growth (review).Mol Med Rep. 2012 Apr;5(4):883-9. doi: 10.3892/mmr.2012.763. Epub 2012 Jan 24. Mol Med Rep. 2012. PMID: 22294146 Free PMC article. Review.
-
CALN1 hypomethylation as a biomarker for high-risk bladder cancer.BMC Urol. 2022 Nov 9;22(1):176. doi: 10.1186/s12894-022-01136-y. BMC Urol. 2022. PMID: 36352401 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Miscellaneous
