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. 2003 Apr 10;46(8):1283-5.
doi: 10.1021/jm0340400.

Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase

Laval Chan  1 , T Jagadeeswar Reddy, Mélanie Proulx, Sanjoy K Das, Oswy Pereira, Wuyi Wang, Arshad Siddiqui, Constantin G Yannopoulos, Carl Poisson, Nathalie Turcotte, Alexandre Drouin, M Hicham Alaoui-Ismaili, Richard Bethell, Martine Hamel, Lucille L'Heureux, Darius Bilimoria, Nghe Nguyen-Ba
Affiliations

Identification of N,N-disubstituted phenylalanines as a novel class of inhibitors of hepatitis C NS5B polymerase

Laval Chan et al. J Med Chem. .

Abstract

The HCV NS5B RNA dependent RNA polymerase plays an essential role in viral replication. The discovery of a novel class of inhibitors based on an N,N-disubstituted phenylalanine scaffold and structure-activity relationships studies to improve potency are described.

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