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Review
. 2003 Apr;13(2):207-14.
doi: 10.1016/s0959-437x(03)00014-5.

Looking at mRNA decay pathways through the window of molecular evolution

Michael R Culbertson  1 , Peter F Leeds
Affiliations
Review

Looking at mRNA decay pathways through the window of molecular evolution

Michael R Culbertson et al. Curr Opin Genet Dev. 2003 Apr.

Abstract

In eukaryotes, mRNAs are monitored for errors in gene expression by RNA surveillance where untranslatable mRNAs are selectively degraded by the nonsense-mediated mRNA decay (NMD) pathway. Depending on the organism, three to seven genes are required for NMD. Besides RNA surveillance, the genes required for NMD serve a second purpose by controlling the overall abundance of a substantial fraction of the transcriptome.

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