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. 2003 Mar;34(3):214-21.
doi: 10.1053/hupa.2003.30.

Genetic instability in superficial bladder cancer and adjacent mucosa: an interphase cytogenetic study

Anna Maria Cianciulli  1 , Costantino Leonardo, Fiorella Guadagni, Raffaella Marzano, Francesco Iori, Cosimo De Nunzio, Giorgio Franco, Roberta Merola, Cesare Laurenti
Affiliations

Genetic instability in superficial bladder cancer and adjacent mucosa: an interphase cytogenetic study

Anna Maria Cianciulli et al. Hum Pathol. 2003 Mar.

Abstract

A systematic analysis of both tumors and the surrounding urothelium to help identify what lies behind the mechanism of multifocal tumor development has not yet been performed. In this study we investigated chromosome 1, 7, 9, and 17 aneusomy in 25 superficial papillary carcinomas and in 51 tissue samples taken from sites of macroscopically uninvolved urothelium surrounding the tumors, using the fluorescence in situ hybridization method. Our data demonstrated a close genetic relationship between all examined tumors and normal-appearing mucosa. Numeric aberrations of chromosomes 1, 7, 9, and 17 were found to exhibit similar patterns in all analyzed specimens, although with different frequencies.

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