Review
doi: 10.1016/s0960-9822(03)00199-4.
Notch signaling: endocytosis makes delta signal better
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- PMID: 12676105
- DOI: 10.1016/s0960-9822(03)00199-4
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Review
Notch signaling: endocytosis makes delta signal better
Curr Biol.
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Free article
Abstract
Endocytosis of cell surface receptors is involved in down-regulation of receptor activity. Recent findings indicate that, paradoxically, endocytosis of a membrane-spanning ligand may up-regulate receptor activity: the zebrafish E3 ligase Mind bomb promotes the endocytosis of Delta and is required for efficient activation of Notch.
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