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Comparative Study
. 2003 Jan-Feb;43(1):51-5.

[NO-inhibiting activity of radioprotectors]

[Article in Russian]
S Ia Proskuriakov  1 , N G Kucherenko, M N Semenenko, A I Trishkina, T P Trofimova, L V Shteĭn, Iu G Verkhovskiĭ, A G Konopliannikov, A A Mandrugin, V M Fedoseev, V G Skvortsov
Affiliations
  • PMID: 12677658
Comparative Study

[NO-inhibiting activity of radioprotectors]

[Article in Russian]
S Ia Proskuriakov et al. Radiats Biol Radioecol. 2003 Jan-Feb.

Abstract

The effect of radioprotectors of different structure on the syntheses of nitric oxide induced by endotoxin in mice was studied. Using ESR-spectroscopy and spin trap techniques, it was shown that compounds of different chemical structure, such as aminothiols, isothiuronium derivatives, thiazolines, indolylalkylamines and others, suppressed the nitric oxide production in a whole body. The analysis of the relevant literature has confirmed the phenomenon described by the authors: radioprotectors show NO-inhibiting activity.

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