Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 Apr;33(4):411-8.
doi: 10.1038/bjc.1976.66.

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine

G Reznik, U Mohr, N Kmoch
Free PMC article

Carcinogenic effects of different nitroso-compounds in Chinese hamsters. I. Dimethylnitrosamine and N-diethylnitrosamine

G Reznik et al. Br J Cancer. 1976 Apr.
Free PMC article

Abstract

Three hundred and twenty Chinese hamsters (Cricetulus griseus) (CH) were treated (s.c.) with 1/5, 1/10 or 1/20 LD50 of dimethylnitrosamine (DMN) or N-diethylnitrosamine (DEN). These substances, in several respects, showed a different organotropy in this species than in both the Syrian golden (SGH) and the European hamster (EH). In CH, DEN produced up to 100% squamous cell papillomata and occasionally also carcinomata of the cheek pouch, tongue, pharynix, oesophagus and forestomach. With DEN a high rate of hepatomata was simultaneously realized. DMN induced a considerable quantity of liver tumours, the highest incidence being demonstrated in the lowest dosage group.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1974;81(3-4):251-9 - PubMed
    1. Br J Cancer. 1974 May;29(5):359-64 - PubMed
    1. J Natl Cancer Inst. 1973 Oct;51(4):1295-301 - PubMed
    1. J Natl Cancer Inst. 1974 Jul;53(1):231-7 - PubMed
    1. Proc Soc Exp Biol Med. 1971 Jan;136(1):168-73 - PubMed