Review
doi: 10.1016/s1471-4892(03)00002-x.
ALK5 inhibition in renal disease
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- PMID: 12681245
- DOI: 10.1016/s1471-4892(03)00002-x
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Review
ALK5 inhibition in renal disease
Curr Opin Pharmacol.
2003 Apr.
Abstract
Recent advances have identified novel small molecule inhibitors of the transforming growth factor-beta (TGF-beta) type I receptor kinase as a potential therapy in organ remodeling diseases, such as chronic renal disease. Because TGF-beta is central to the progression of fibrosis, selective inhibition of this signaling pathway could provide a novel treatment in many fibrotic diseases. The rationale for inhibition of TGF-beta signaling in renal disease includes prevention of fibrosis, tubular dedifferentiation and vascular effects.
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