Review
doi: 10.1016/s1286-4579(03)00013-3.
Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells
Affiliations
- PMID: 12681410
- DOI: 10.1016/s1286-4579(03)00013-3
Item in Clipboard
Review
Regulation of the generation and maintenance of T-cell memory: a direct, default pathway from effectors to memory cells
Microbes Infect.
2003 Mar.
Free article
Abstract
Memory T cells are derived directly from effector cells without need for additional antigen, TcR triggering or induced cytokines. A large fraction of effectors can become memory cells without division, supporting a default pathway with little further differentiation. This suggests that the same signals during infection/vaccination determine the extent and nature of both effector and memory cell development.
Similar articles
-
CD4(+) T cell effectors can become memory cells with high efficiency and without further division.Nat Immunol. 2001 Aug;2(8):705-10. doi: 10.1038/90643. Nat Immunol. 2001. PMID: 11477406
-
The multifaceted role of CD4(+) T cells in CD8(+) T cell memory.Nat Rev Immunol. 2016 Feb;16(2):102-11. doi: 10.1038/nri.2015.10. Epub 2016 Jan 19. Nat Rev Immunol. 2016. PMID: 26781939 Free PMC article. Review.
-
IL-15 induces type 1 and type 2 CD4+ and CD8+ T cells proliferation but is unable to drive cytokine production in the absence of TCR activation or IL-12 / IL-4 stimulation in vitro.Eur J Immunol. 2002 Feb;32(2):341-7. doi: 10.1002/1521-4141(200202)32:2<341::AID-IMMU341>3.0.CO;2-X. Eur J Immunol. 2002. PMID: 11807773
-
Reversing tumor immune suppression with intratumoral IL-12: activation of tumor-associated T effector/memory cells, induction of T suppressor apoptosis, and infiltration of CD8+ T effectors.J Immunol. 2006 Nov 15;177(10):6962-73. doi: 10.4049/jimmunol.177.10.6962. J Immunol. 2006. PMID: 17082611
-
Similarities and differences in CD4+ and CD8+ effector and memory T cell generation.Nat Immunol. 2003 Sep;4(9):835-42. doi: 10.1038/ni969. Nat Immunol. 2003. PMID: 12942084 Review.
Cited by
-
CD4+ T-cell memory: generation and multi-faceted roles for CD4+ T cells in protective immunity to influenza.Immunol Rev. 2006 Jun;211:8-22. doi: 10.1111/j.0105-2896.2006.00388.x. Immunol Rev. 2006. PMID: 16824113 Free PMC article. Review.
-
Cellular and Molecular Immunity to Influenza Viruses and Vaccines.Vaccines (Basel). 2024 Apr 7;12(4):389. doi: 10.3390/vaccines12040389. Vaccines (Basel). 2024. PMID: 38675771 Free PMC article. Review.
-
Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome.Microbes Infect. 2005 Mar;7(3):427-36. doi: 10.1016/j.micinf.2004.11.017. Epub 2005 Feb 24. Microbes Infect. 2005. PMID: 15784184 Free PMC article.
-
Generation, persistence and plasticity of CD4 T-cell memories.Immunology. 2010 Aug;130(4):463-70. doi: 10.1111/j.1365-2567.2010.03288.x. Epub 2010 May 10. Immunology. 2010. PMID: 20465569 Free PMC article. Review.
-
Low-dose antigen-experienced CD4+ T cells display reduced clonal expansion but facilitate an effective memory pool in response to secondary exposure.Immunology. 2008 Mar;123(3):426-37. doi: 10.1111/j.1365-2567.2007.02707.x. Epub 2007 Oct 4. Immunology. 2008. PMID: 17916164 Free PMC article.
Publication types
MeSH terms
LinkOut - more resources
Full Text Sources
