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Comment
. 2003 Apr 15;100(8):4363-5.
doi: 10.1073/pnas.0931010100. Epub 2003 Apr 7.

Radar breaks the fog: insights into dorsoventral patterning in zebrafish

Thomas P Wilm  1 , Lilianna Solnica-Krezel
Affiliations
Comment

Radar breaks the fog: insights into dorsoventral patterning in zebrafish

Thomas P Wilm et al. Proc Natl Acad Sci U S A. .
No abstract available

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Figures

Figure 1
Figure 1
BMP signaling pathway (see text for details).
Figure 2
Figure 2
Fate specification in zebrafish embryos at the onset of gastrulation. In wild type, the BMP activity gradient is set up by the combination of positive autoregulation and negative regulation through BMP-antagonists like Chordin. In the absence of Chordin and Bozozok, the influence of BMP signaling expands dorsally, and ventral tissues such as posterior somitic mesoderm and blood are enlarged. Inactivation of bmp2b causes the opposite scenario; activity of BMP dramatically increases leading to the induction of excessive dorsal fates like neuroectoderm and anterior somitic mesoderm.
Figure 3
Figure 3
Model of the maternal Radar signaling pathway mediating early steps of dorsoventral axis formation. Radar acts through the TGF-β type I receptor Alk8 and causes transcriptional activation of BMP2b and BMP4. The intracellular signal transducer, believed to be a member of the Smad1/5/8 protein family is not known (indicated in gray), although Smad5 may be excluded. Maternal Smad5 may transduce the signal of a hypothesized distinct maternal signaling pathway acting in parallel to Radar. Alk8 is also the receptor for zygotic BMP2b/7 signaling, and Smad5 transduces that signal, leading to the autoregulatory transcriptional activation of BMP2b/4/7.
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