doi: 10.1016/0005-2787(76)90135-0.
The effect of 313 nanometer light on initiation of replicons in mammalian cell DNA containing bromodeoxyuridine
- PMID: 1268255
- DOI: 10.1016/0005-2787(76)90135-0
Item in Clipboard
The effect of 313 nanometer light on initiation of replicons in mammalian cell DNA containing bromodeoxyuridine
Biochim Biophys Acta.
.
Abstract
After unifilar substitution of thymine with bromouracil in either human HeLa or bovine cells, exposure to 313 nm light inhibits initiation of clusters of replicons. Since this treatment results in damage only to DNA and because the effect is the same as observed after 100-1000 rads of X-ray irradiation to the same cells, we infer that the effect of the later treatment is also mediated almost exclusively by DNA damage.
Similar articles
-
Replicon sizes in mammalian cells as estimated by an x-ray plus bromodeoxyuridine photolysis method.Biophys J. 1978 Dec;24(3):739-48. doi: 10.1016/S0006-3495(78)85417-4. Biophys J. 1978. PMID: 570067 Free PMC article.
-
Formation of nascent DNA molecules during inhibition of replicon initiation in mammalian cells.Biochim Biophys Acta. 1976 Jan 19;418(2):146-53. doi: 10.1016/0005-2787(76)90063-0. Biochim Biophys Acta. 1976. PMID: 1247539
-
The timecourse of DNA repair replication in ultraviolet-irradiated HeLa cells.Biochim Biophys Acta. 1973 Oct 12;324(2):206-17. doi: 10.1016/0005-2787(73)90138-x. Biochim Biophys Acta. 1973. PMID: 4271371 No abstract available.
-
Repair in mammalian cells: overview.Basic Life Sci. 1975;5B:595-600. doi: 10.1007/978-1-4684-2898-8_27. Basic Life Sci. 1975. PMID: 1103875 Review. No abstract available.
-
Ultraviolet action spectra in perspective: with special reference to mutation.Photochem Photobiol. 1968 Dec;8(6):527-46. doi: 10.1111/j.1751-1097.1968.tb05897.x. Photochem Photobiol. 1968. PMID: 4886670 Review. No abstract available.
Cited by
-
Radiosensitivity in ataxia-telangiectasia: a new explanation.Proc Natl Acad Sci U S A. 1980 Dec;77(12):7315-7. doi: 10.1073/pnas.77.12.7315. Proc Natl Acad Sci U S A. 1980. PMID: 6938978 Free PMC article.
-
Rate of DNA chain elongation in ultraviolet light-irradiated mammalian cells as estimated by a bromodeoxyuridine photolysis method.Biophys J. 1976 Aug;16(8):883-9. doi: 10.1016/S0006-3495(76)85738-4. Biophys J. 1976. PMID: 938728 Free PMC article.
-
Effects of novobiocin on adenovirus DNA synthesis and encapsidation.Nucleic Acids Res. 1980 Apr 11;8(7):1625-41. doi: 10.1093/nar/8.7.1625. Nucleic Acids Res. 1980. PMID: 7433126 Free PMC article.
-
Changes in repair competency after 5-bromodeoxyuridine pulse labeling and near-ultraviolet light.Biophys J. 1979 Jul;27(1):75-85. doi: 10.1016/S0006-3495(79)85203-0. Biophys J. 1979. PMID: 262378 Free PMC article.
-
Replicon sizes in mammalian cells as estimated by an x-ray plus bromodeoxyuridine photolysis method.Biophys J. 1978 Dec;24(3):739-48. doi: 10.1016/S0006-3495(78)85417-4. Biophys J. 1978. PMID: 570067 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
