[Angiogenesis and lymphangiogenesis in the cornea. Pathogenesis, clinical implications and treatment options]

Abstract

Background: Whereas the normal cornea is devoid of blood and lymphatic vessels,both can invade the cornea secondary to a variety of corneal diseases and after surgery. This not only reduces visual acuity, but also renders such a cornea high-risk, if subsequent corneal transplantation is performed.

Methods: A PUBMED-based literature search was carried out.

Results: Current knowledge on pathogenesis, clinical implications and treatment modalities for corneal neovascularization is discussed.

Conclusions: Novel anti-angiogenic and antilymphangiogenic therapeutic strategies should reduce blindness associated with corneal neovascularization and subsequent graft rejection.