Review
doi: 10.1007/s00347-003-0802-6.
[Pathogenesis of choroidal neovascularization. Old concepts, new questions]
[Article in
German]
Affiliations
- PMID: 12682762
- DOI: 10.1007/s00347-003-0802-6
Item in Clipboard
Review
[Pathogenesis of choroidal neovascularization. Old concepts, new questions]
[Article in
German]
Ophthalmologe.
2003 Apr.
Abstract
Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world but the pathogenesis remains poorly understood. Malfunction of the retinal pigment epithelium (RPE) plays a central role in the disease and leads to either choriodal atrophy or proliferation. This article reviews the current concepts of the development of choriodal atrophy and neovascularisation. Furthermore, available animal models and potential therapeutical targets are discussed.
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