doi: 10.1016/s0021-9673(02)01971-4.
Analysis of the active components of silymarin
Affiliations
- PMID: 12685603
- DOI: 10.1016/s0021-9673(02)01971-4
Item in Clipboard
Analysis of the active components of silymarin
J Chromatogr A.
.
Abstract
Silymarin is an antihepatotoxic substance isolated from fruits of Silybum marianum. Possibly due to their antioxidant and membrane stabilizing properties, the compounds have been shown to protect different organs and cells against a number of insults. The content and composition of main silymarin components (silybin, isosilybin, silydianin and silychristin) in various pharmaceuticals were analysed using HPLC and newly developed capillary zone electrophoresis method. Antioxidant properties expressed as total antioxidant status (TAS) of silymarin components were studied. Results of TAS were correlated with electropherograms and chromatograms.
Similar articles
-
The study of flavonolignan association patterns in fruits of diverging Silybum marianum (L.) Gaertn. chemotypes provides new insights into the silymarin biosynthetic pathway.Phytochemistry. 2017 Dec;144:9-18. doi: 10.1016/j.phytochem.2017.08.013. Epub 2017 Sep 1. Phytochemistry. 2017. PMID: 28863306
-
Variation in the flavonolignan composition of fruits from different Silybum marianum chemotypes and suspension cultures derived therefrom.Phytochemistry. 2016 Nov;131:68-75. doi: 10.1016/j.phytochem.2016.09.003. Epub 2016 Sep 14. Phytochemistry. 2016. PMID: 27639292
-
Simplified procedure of silymarin extraction from Silybum marianum L. Gaertner.J Chromatogr Sci. 2015 Feb;53(2):366-72. doi: 10.1093/chromsci/bmu049. Epub 2014 Jun 3. J Chromatogr Sci. 2015. PMID: 24895445
-
Recapitulation of Evidence of Phytochemical, Pharmacokinetic and Biomedical Application of Silybin.Drug Res (Stuttg). 2021 Nov;71(9):489-503. doi: 10.1055/a-1528-2721. Epub 2021 Jul 27. Drug Res (Stuttg). 2021. PMID: 34318464 Review.
-
The silymarin composition… and why does it matter???Food Res Int. 2017 Oct;100(Pt 3):339-353. doi: 10.1016/j.foodres.2017.07.017. Epub 2017 Jul 12. Food Res Int. 2017. PMID: 28964357 Review.
Cited by
-
Baicalein Enhances the Oral Bioavailability and Hepatoprotective Effects of Silybin Through the Inhibition of Efflux Transporters BCRP and MRP2.Front Pharmacol. 2018 Oct 26;9:1115. doi: 10.3389/fphar.2018.01115. eCollection 2018. Front Pharmacol. 2018. PMID: 30416442 Free PMC article.
-
Physiological and biochemical characteristics of milk thistle (Silybum marianum (L.) Gaertn) as affected by some plant growth regulators.Food Sci Nutr. 2024 Jun 11;12(8):6022-6033. doi: 10.1002/fsn3.4233. eCollection 2024 Aug. Food Sci Nutr. 2024. PMID: 39139968 Free PMC article.
-
Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila.Sci Rep. 2023 Sep 27;13(1):16235. doi: 10.1038/s41598-023-43270-z. Sci Rep. 2023. PMID: 37758826 Free PMC article.
-
Biotransformation of Silymarin Flavonolignans by Human Fecal Microbiota.Metabolites. 2020 Jan 9;10(1):29. doi: 10.3390/metabo10010029. Metabolites. 2020. PMID: 31936497 Free PMC article.
-
Detecting and Profiling of Milk Thistle Metabolites in Food Supplements: A Safety-Oriented Approach by Advanced Analytics.Metabolites. 2023 Mar 17;13(3):440. doi: 10.3390/metabo13030440. Metabolites. 2023. PMID: 36984880 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
