Review
doi: 10.1016/s1570-9639(03)00077-3.
The multi-functional topa-quinone copper amine oxidases
Affiliations
- PMID: 12686122
- DOI: 10.1016/s1570-9639(03)00077-3
Item in Clipboard
Review
The multi-functional topa-quinone copper amine oxidases
Biochim Biophys Acta.
.
Abstract
The mature copper amine oxidases (CAOs) contain a tyrosine-derived 2,4,5-trihydroxyphenylalanyl quinone (topa quinone or TPQ) and a cupric ion in close proximity. Through a combination of structural, spectroscopic and kinetic analyses, a chemical mechanism for the self-processing of an active site tyrosine to TPQ has been proposed. Once formed, TPQ acts as a switch between the heterolytic transformation of amine substrates to aldehydes, via a pyridoxal phosphate-like Schiff base complex, and one electron chemistry involving reduction of molecular oxygen. The relationship between the biogenetic and catalytic processes is discussed.
Similar articles
-
Crystal structure at 2.5 A resolution of zinc-substituted copper amine oxidase of Hansenula polymorpha expressed in Escherichia coli.Biochemistry. 2000 Aug 15;39(32):9709-17. doi: 10.1021/bi000639f. Biochemistry. 2000. PMID: 10933787
-
Copper-containing amine oxidases. Biogenesis and catalysis; a structural perspective.Arch Biochem Biophys. 2004 Aug 1;428(1):22-31. doi: 10.1016/j.abb.2004.03.034. Arch Biochem Biophys. 2004. PMID: 15234266 Review.
-
Spectroscopic characterization of carbon monoxide complexes generated for copper/topa quinone-containing amine oxidases.Biochemistry. 1999 Oct 26;38(43):14256-63. doi: 10.1021/bi991129s. Biochemistry. 1999. PMID: 10571999
-
Stoichiometry of the topa quinone biogenesis reaction in copper amine oxidases.Biochemistry. 1999 Mar 9;38(10):2892-8. doi: 10.1021/bi9824994. Biochemistry. 1999. PMID: 10074341
-
Tyrosine-derived quinone cofactors.Acc Chem Res. 2004 Feb;37(2):131-9. doi: 10.1021/ar9703342. Acc Chem Res. 2004. PMID: 14967060 Review.
Cited by
-
Vascular adhesion protein-1 is involved in both acute and chronic inflammation in the mouse.Am J Pathol. 2005 Mar;166(3):793-800. doi: 10.1016/S0002-9440(10)62300-0. Am J Pathol. 2005. PMID: 15743791 Free PMC article.
-
Natural Products Inhibitors of Monoamine Oxidases-Potential New Drug Leads for Neuroprotection, Neurological Disorders, and Neuroblastoma.Molecules. 2022 Jul 4;27(13):4297. doi: 10.3390/molecules27134297. Molecules. 2022. PMID: 35807542 Free PMC article. Review.
-
The Potential of the Yeast Debaryomyces hansenii H525 to Degrade Biogenic Amines in Food.Microorganisms. 2015 Nov 6;3(4):839-50. doi: 10.3390/microorganisms3040839. Microorganisms. 2015. PMID: 27682120 Free PMC article.
-
Copper active sites in biology.Chem Rev. 2014 Apr 9;114(7):3659-853. doi: 10.1021/cr400327t. Epub 2014 Mar 3. Chem Rev. 2014. PMID: 24588098 Free PMC article. Review. No abstract available.
-
Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles.Sci Rep. 2020 Dec 9;10(1):21563. doi: 10.1038/s41598-020-78134-3. Sci Rep. 2020. PMID: 33299054 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
