Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003;2003(1):25-34.
doi: 10.1155/S1110724303209013.

Current and Future Gene Therapy for Malignant Gliomas

Takao Kanzawa, Hideaki Ito, Yasuko Kondo, Seiji Kondo

Current and Future Gene Therapy for Malignant Gliomas

Takao Kanzawa et al. J Biomed Biotechnol. 2003.

Abstract

Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative treatment. Many gene therapeutic approaches have demonstrated efficacy in experimental animal models. However, the current clinical trials are disappointing. This review focuses on current therapeutic genes/vectors/delivery systems/targeting strategies in order to introduce updated trends and hopefully indicate prospective gene therapy for malignant gliomas.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Prospective gene therapy for malignant gliomas.
See this image and copyright information in PMC

References

    1. Schoenberg B S. The epidemiology of central nervous system tumors. In: Walker M D, editor. Oncology of the nervous system. Martinus Nijhoff; Boston: 1983. pp. 1–30.
    1. Mahaley M S. Jr, Mettlin C, Natarajan N, Laws E R. Jr, Peace B B. National survey of patterns of care for brain-tumor patients. J Neurosurg. 1989;71(6):826–836. - PubMed
    1. Deen D F, Chiarodo A, Grimm E A, et al. Brain Tumor Working Group Report on the 9th International Conference on Brain Tumor Research and Therapy. Organ System Program, National Cancer Institute. J Neurooncol. 1993;16(3):243–272. - PubMed
    1. Culver K W, Ram Z, Wallbridge S, Ishii H, Oldfield E H, Blaese R M. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science. 1992;256(5063):1550–1552. - PubMed
    1. Trask T W, Trask R P, Aguilar-Cordova E, et al. Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther. 2000;1(2):195–203. - PubMed

LinkOut - more resources