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. 2003;2003(1):25-34.
doi: 10.1155/S1110724303209013.

Current and Future Gene Therapy for Malignant Gliomas

Takao Kanzawa, Hideaki Ito, Yasuko Kondo, Seiji Kondo

Current and Future Gene Therapy for Malignant Gliomas

Takao Kanzawa et al. J Biomed Biotechnol. 2003.

Abstract

Malignant gliomas are the most common neoplasm in the central nervous system. When treated with conventional treatments including surgery, irradiation, and chemotherapy, the average life expectancy of the most malignant type, glioblastoma multiforme is usually less than 1 year. Therefore, gene therapy is expected to be an effective and possibly curative treatment. Many gene therapeutic approaches have demonstrated efficacy in experimental animal models. However, the current clinical trials are disappointing. This review focuses on current therapeutic genes/vectors/delivery systems/targeting strategies in order to introduce updated trends and hopefully indicate prospective gene therapy for malignant gliomas.

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Figure 1
Prospective gene therapy for malignant gliomas.
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