Dynamic susceptibility contrast MRI of gliomas

Abstract

Dynamic susceptibility contrast imaging has proven to be useful in brain tumor studies, and it provides additional information on tumor characteristics based on the microvascular structure of gliomas. The cerebral blood volume maps can be used to noninvasively grade gliomas, to determine optimal biopsy sites, to separate radiation necrosis from tumor regrowth, and to plan and follow irradiation, chemo- and antiangiogenic therapy. Besides of cerebral blood volume mapping, dynamic susceptibility contrast imaging sets also contain information about the flow and permeability properties of the tumor microvascular system. When combined with the conventional MRI, dynamic susceptibility contrast techniques offer important functional information about the biology of gliomas in a cost-effective way.