The effect of arterial oxygen tension on antipyrine half-time in plasma
- PMID: 1269198
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The effect of arterial oxygen tension on antipyrine half-time in plasma
Clin Pharmacol Ther.
1976 Apr.
Abstract
Hospital patients with depressed arterial oxygen tensions (PaO2) from pulmonary disease were given antipyrine orally or intravenously. The half-time (t1/2) of disappearance from plasma was measured. Other patients with normal PaO2 measurements were treated similarly. Patients whose PaO2 was 55 or below had longer t1/2 times than those of patients with a PaO2 above 55. This observation parallels that made previously in rats.
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