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Case Reports
. 2003 Apr;18(2):299-300.
doi: 10.3346/jkms.2003.18.2.299.

Flumazenil-induced ballism

Joong-Seok Kim  1 , Seok-Bum Ko, Yeong-Bin Choi, Kwang-Soo Lee
Affiliations
Case Reports

Flumazenil-induced ballism

Joong-Seok Kim et al. J Korean Med Sci. 2003 Apr.

Abstract

Flumazenil, an imidazobenzodiazepine, is the first benzodiazepine antagonist and is being used to reverse the adverse pharmacological effects of benzodiazepine. There have been a few reports on the central nevous system side effects with its use. We report a patient with generalized ballism following administration of flumazenil. The mechanism through which flumazenil induced this symptom is unknown. It is conceivable that flumazenil may antagonize the GABA-benzodiazepine receptor complex and induce dopamine hypersensitivity, thus induce dyskinesic symptoms.

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