Ablation of striatal interneurons influences activities of entopeduncular neurons

Abstract

To characterize modulatory effects of striatal interneurons upon the output nucleus of the basal ganglia, we ablated striatal interneurons that express substance P receptors by using local injection of a selective neurotoxin, substance P-saporin, in rats. We then made extracellular recordings of the activity of entopeduncular neurons and examined their responses to stimulation in the motor cortex. In the interneuron-ablated animals, the spontaneous discharge rate of entopeduncular neurons was significantly decreased, and the proportion of entopeduncular neurons showing responses to cortical stimulation was significantly larger, in comparison with intact animals. It is suggested that striatal interneurons expressing substance P receptors are important for motor control mechanisms mediated by the cortico-basal ganglia pathways.