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Case Reports
. 2003 May;10(5):271-3.
doi: 10.1046/j.1442-2042.2003.00620.x.

Malignant transformation of renal angiomyolipoma

Nobuyoshi Takahashi  1 , Ryuji Kitahara, Yasuyuki Hishimoto, Akimitsu Ohguro, Yasuhiro Hashimoto, Tadashi Suzuki
Affiliations
Free article
Case Reports

Malignant transformation of renal angiomyolipoma

Nobuyoshi Takahashi et al. Int J Urol. 2003 May.
Free article

Abstract

In the present paper, two cases of malignant transformation of renal angiomyolipoma without tuberous sclerosis are reported. Pathological examination revealed that, in both cases, in addition to the areas affected by typical angiomyolipoma, there were areas that contained elevated numbers of perivascular epithelioid cells with prominent nuclear pleomorphism. Immunohistochemical examination revealed that both cases were negative for keratin and epithelial membrane antigen, but were positive for the melanogenesis-related marker HMB-45. Metastatic diseases appeared 40 months after radical nephrectomy in the first case and 18 months in the second case.

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