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. 2003 Apr 23;125(16):4704-5.
doi: 10.1021/ja0292748.

Highly enantioselective quinoline synthesis via ene-type cyclization of 1,7-enynes catalyzed by a cationic BINAP-palladium(II) complex

Manabu Hatano  1 , Koichi Mikami
Affiliations

Highly enantioselective quinoline synthesis via ene-type cyclization of 1,7-enynes catalyzed by a cationic BINAP-palladium(II) complex

Manabu Hatano et al. J Am Chem Soc. .

Abstract

The first highly enantioselective synthesis of a six-membered ring quinoline catalyzed by a cationic BINAP-palladium(II) complex is shown to afford the quinoline products having a quaternary carbon center or a spiro-ring in quantitative yield and >99% ee.

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