doi: 10.1093/jac/dkg218.
Epub 2003 Apr 14.
In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera
Affiliations
- PMID: 12697648
- DOI: 10.1093/jac/dkg218
Item in Clipboard
In vitro activity of amphotericin B and itraconazole in combination with flucytosine, sulfadiazine and quinolones against Exophiala spinifera
J Antimicrob Chemother.
2003 May.
Abstract
The combined effects of antifungal and antibiotic drugs against Exophiala spinifera were evaluated in vitro by the chequer-board method, calculated as a fractional inhibitory concentration (FIC) index. Amphotericin B was combined with flucytosine and ciprofloxacin, whereas itraconazole was combined with ciprofloxacin, levofloxacin, lomefloxacin and sulfadiazine. Synergic effects were observed for the combinations of itraconazole with ciprofloxacin and levofloxacin, and amphotericin B with ciprofloxacin and flucytosine. No antagonism was observed for any combination tested.
Similar articles
-
In-vitro activity of antifungal agents in combination with four quinolones.Drugs Exp Clin Res. 1988;14(1):9-18. Drugs Exp Clin Res. 1988. PMID: 3292181
-
In vitro activities of five antifungal agents against pathogenic Exophiala species.Chin Med J (Engl). 1999 Jun;112(6):484-8. Chin Med J (Engl). 1999. PMID: 11601322
-
Effect of pH on the in vitro activities of amphotericin B, itraconazole, and flucytosine against Aspergillus isolates.Antimicrob Agents Chemother. 2004 Aug;48(8):3147-50. doi: 10.1128/AAC.48.8.3147-3150.2004. Antimicrob Agents Chemother. 2004. PMID: 15273136 Free PMC article.
-
[Antimicrobial drug therapy and microbial sensitivity tests--antifungal agents and microbial sensitivity tests].Rinsho Byori. 1997 Jul;Suppl 105:182-90. Rinsho Byori. 1997. PMID: 9379538 Review. Japanese. No abstract available.
-
[The activity of systemic antimycotic drug combinations].Rev Esp Quimioter. 2001 Mar;14(1):30-9. Rev Esp Quimioter. 2001. PMID: 11376347 Review. Spanish.
Cited by
-
Quaternized Polysulfones as Matrix for the Development of Broad-Spectrum Antimicrobial Coatings for Medical Devices.Polymers (Basel). 2025 Jul 3;17(13):1869. doi: 10.3390/polym17131869. Polymers (Basel). 2025. PMID: 40647878 Free PMC article.
-
Candida species distribution in bloodstream cultures in Lyon, France, 1998-2001.Eur J Clin Microbiol Infect Dis. 2005 May;24(5):329-33. doi: 10.1007/s10096-005-1321-y. Eur J Clin Microbiol Infect Dis. 2005. PMID: 15856138
-
Flucytosine and its clinical usage.Ther Adv Infect Dis. 2023 Apr 5;10:20499361231161387. doi: 10.1177/20499361231161387. eCollection 2023 Jan-Dec. Ther Adv Infect Dis. 2023. PMID: 37051439 Free PMC article. Review.
-
Cutaneous and mucosal phaeohyphomycosis caused by Exophiala spinifera in a pregnant patient: case report and literature review.Mycopathologia. 2013 Apr;175(3-4):331-8. doi: 10.1007/s11046-012-9611-2. Epub 2013 Jan 20. Mycopathologia. 2013. PMID: 23334555
-
Combination of Amphotericin B and Flucytosine against Neurotropic Species of Melanized Fungi Causing Primary Cerebral Phaeohyphomycosis.Antimicrob Agents Chemother. 2016 Mar 25;60(4):2346-51. doi: 10.1128/AAC.02526-15. Print 2016 Apr. Antimicrob Agents Chemother. 2016. PMID: 26833164 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
