Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Apr;111(8):1107-13.
doi: 10.1172/JCI18338.

The organization and consequences of eicosanoid signaling

Roy J Soberman  1 , Peter Christmas
Affiliations
Review

The organization and consequences of eicosanoid signaling

Roy J Soberman et al. J Clin Invest. 2003 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
LT biosynthesis and assembly. Upon cellular activation of a mast cell or macrophage by IgE-antigen complexes or other stimuli, a cascade of cell activation events results in LT biosynthesis. A concomitant rise in free calcium induces translocation of cPLA2 to intracellular membranes, where it releases arachidonic acid. In parallel, 5-LO is phosphorylated by MAP kinase kinase and traffics through the nuclear pore to the nucleus (possibly in association with NF-κB) or directly to the outer nuclear envelope. 5-LO then associates with the nuclear membrane, and possibly with FLAP. FLAP facilitates arachidonic acid presentation to 5-LO and subsequent conversion of arachidonic acid to LTA4. LTA4 interacts with LTA4 hydrolase to form LTB4, or with LTC4 synthase to form LTC4. The synthesis of LTs A4, B4, and C4probably takes place within the lumen of, or in close proximity to, the nuclear membranes. However, for clarity they are shown here throughout the cytosol. FLAP is present on both the inner and the outer nuclear envelope, but LTC4 synthase is exclusively expressed on the outer nuclear membrane and ER.
Figure 2
Figure 2
Membrane topology of proteins involved in eicosanoid synthesis. The active sites of LTC4 synthase, COX1, COX2, and the lipid-binding domain of FLAP are all oriented to the lumen of the ER and the nuclear envelope.
See this image and copyright information in PMC

References

    1. Soberman RJ. The expanding network of redox signaling: new observations, complexities, and perspectives. J. Clin. Invest. 2003;111:571–574. doi:10.1172/JCI200318099. - PMC - PubMed
    1. Lewis RA, Austen KF, Soberman RJ. Leukotrienes and other products of the 5-lipoxygenase pathway. Biochemistry and relation to pathobiology in human diseases. N. Engl. J. Med. 1990;323:645–655. - PubMed
    1. Samuelsson B, et al. Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science. 1987;237:1171–1177. - PubMed
    1. Weller PF, et al. Generation and metabolism of 5-lipoxygenase pathway leukotrienes by human eosinophils: predominant production of leukotriene C. Proc. Natl. Acad. Sci. U. S. A. 1983;80:7626–7630. - PMC - PubMed
    1. Owen WF, Jr, et al. Synthesis and release of leukotriene C4, by human eosinophils. J. Immunol. 1987;138:532–538. - PubMed

Publication types