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Comment
. 2003 Apr;111(8):1122-4.
doi: 10.1172/JCI18384.

Azathioprine: old drug, new actions

Jonathan S Maltzman  1 , Gary A Koretzky
Affiliations
Comment

Azathioprine: old drug, new actions

Jonathan S Maltzman et al. J Clin Invest. 2003 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Schematic of extracellular and intracellular T cell–signaling pathways targeted by immunosuppressive medications. The IL-2 receptor (IL-2R) and CD28 molecules are shown; daclizumab and CTLA4-Ig, respectively, block interaction of these cell-surface receptors with their ligands. OKT3 interacts with the TCR-associated CD3 complex. Rapamycin inhibits cell cycle progression through its interaction with mTOR. Cyclosporin A and tacrolimus inhibit calcineurin, thereby inhibiting NFAT and IL-2 synthesis. Azathioprine, through its 6-ThioGTP metabolite, inhibits CD28 signals.
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