Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1976 May;12(2):149-54.
doi: 10.1007/BF00428981.

Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats

K F Kankel, H Reinauer

Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats

K F Kankel et al. Diabetologia. 1976 May.

Abstract

After parturition there is a 10 fold increase in the actual and total activity of the PDH complex in the mammary gland, which can be explained by an increased amount of enzyme protein. There is a marked difference between the activity state of the PDH complex in the suckled and unsuckled gland of the same animals. In fasting rats the active form of the PDH complex is decreased. This effect is further enhanced by inhibition of suckling. In the diabetic state the PDHa activity is reduced, but the change is statistically insignificant. The decreased milk production during diabetes results from the reduction of the total mass of gland. The total activity of the PDH complex is the same in fetal and neonatal liver of the rat. Whereas the PDH complex is fully activated before parturition, there is a significant decrease in the active form of the pyruvate dehydrogenase complex in the liver of the newborn rats.

PubMed Disclaimer

References

    1. Biochem J. 1972 Aug;128(5):1303-9 - PubMed
    1. Proc Soc Exp Biol Med. 1973 Mar;142(3):954-62 - PubMed
    1. Hoppe Seylers Z Physiol Chem. 1968 Aug;349(8):969-78 - PubMed
    1. Biochem Biophys Res Commun. 1972 Oct 17;49(2):563-71 - PubMed
    1. Biochem J. 1974 May;140(2):225-37 - PubMed

Substances