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Case Reports
. 1976 Jun;70(6):1144-7.

Piperazine hepatitis

A N Hamlyn, J S Morris, I Sarkany, S Sherlock
  • PMID: 1269876
Case Reports

Piperazine hepatitis

A N Hamlyn et al. Gastroenterology. 1976 Jun.

Abstract

The first reported case of piperazine toxicity resembling viral hepatitis is described in a 25-year-old woman. The illness, which was severe, occurred after administration of the drug on two separate occasions. The evidence favors a hypersensitivity mechanism rather than a direct toxic effect of piperazine or its metabolites on the liver. The humoral or cellular immune basis for such hypersensitivity has not been elucidated.

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