Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003 Apr 24;46(9):1567-70.
doi: 10.1021/jm0340039.

The pharmacophore of short cationic antibacterial peptides

Morten B Strøm  1 , Bengt Erik Haug, Merete L Skar, Wenche Stensen, Trine Stiberg, John S Svendsen
Affiliations

The pharmacophore of short cationic antibacterial peptides

Morten B Strøm et al. J Med Chem. .

Abstract

Cationic antibacterial peptides have been proclaimed as new drugs against multiresistant bacteria. Their limited success so far is partially due to the size of the peptides, which gives rise to unresolved issues regarding administration, bioavailability, metabolic stability, and immunogenicity. We have systematically investigated the minimum antibacterial motif of cationic antibacterial peptides regarding charge and lipophilicity/bulk and found that the pharmacophore was surprisingly small, opening the opportunity for development of short antibacterial peptides for systemic use.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources