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Review
. 2003 May 1:8:d855-69.
doi: 10.2741/1097.

Function of bone morphogenetic protein signaling during mouse development

Yuji Mishina  1
Affiliations
Review

Function of bone morphogenetic protein signaling during mouse development

Yuji Mishina. Front Biosci. .

Abstract

Bone morphogenetic proteins (BMPs) play pleiotropic roles during development and after birth in many different organisms. BMPs are members of TGF-beta superfamily. There are more than 20 members with three type II receptors and three type I receptors. Genetic approaches using the mouse as a model system revealed many of the functions of BMPs. Particularly, results obtained through loss-of-function analyses of BMP ligands and their receptors are reviewed in this article.

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