doi: 10.1007/BF00291497.
Distribution of spontaneous chromosome breaks in human chromosomes
- PMID: 1270073
- DOI: 10.1007/BF00291497
Item in Clipboard
Distribution of spontaneous chromosome breaks in human chromosomes
Hum Genet.
.
Abstract
Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.
Similar articles
-
Nonrandom distribution of chromosome breaks in cultured lymphocytes of normal subjects.Hum Genet. 1976 Feb 29;31(2):161-75. doi: 10.1007/BF00296144. Hum Genet. 1976. PMID: 1248828
-
The effect of caffeine on chromosomes of human lymphocytes: non-random distribution of damage.Mutat Res. 1973 Dec;20(3):441-3. doi: 10.1016/0027-5107(73)90066-3. Mutat Res. 1973. PMID: 4778858 No abstract available.
-
[Chromosome aberrations in abortions].Ann Genet. 1967 Dec;10(4):179-87. Ann Genet. 1967. PMID: 5301690 French. No abstract available.
-
Chromosomes and abortion.Adv Hum Genet. 1971;2:201-57. Adv Hum Genet. 1971. PMID: 4950477 Review. No abstract available.
-
[The autosomal chromosome aberrations in ophthalmology].J Genet Hum. 1966;15:Suppl:133-208. J Genet Hum. 1966. PMID: 4873685 Review. French. No abstract available.
Cited by
-
Unstable familial translocations: A t(11;22)mat inherited as a t(11;15).Am J Hum Genet. 1981 Sep;33(5):745-51. Am J Hum Genet. 1981. PMID: 7294023 Free PMC article.
-
The constitutional fragility of chromosome 12 in a case of 46,XX,var(12)(gh',RHG,CAG,CBG).Hum Genet. 1979 Apr 17;48(1):53-9. doi: 10.1007/BF00273274. Hum Genet. 1979. PMID: 457134
-
DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.Hum Genet. 1984;67(2):136-42. doi: 10.1007/BF00272988. Hum Genet. 1984. PMID: 6430783
-
Multicolor FISH analysis of chromosomal breaks, duplications, deletions, and numerical abnormalities in the sperm of healthy men.Am J Hum Genet. 2000 Oct;67(4):862-72. doi: 10.1086/303088. Epub 2000 Aug 28. Am J Hum Genet. 2000. PMID: 10961911 Free PMC article.
-
Partial deletion of the short arm of chromosome 3.Eur J Pediatr. 1981 May;136(2):211-6. doi: 10.1007/BF00441927. Eur J Pediatr. 1981. PMID: 7227394