Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Apr;81(4):218-26.
doi: 10.1007/s00109-003-0428-9. Epub 2003 Mar 28.

Resistin: molecular history and prognosis

Ronadip R Banerjee  1 , Mitchell A Lazar
Affiliations
Review

Resistin: molecular history and prognosis

Ronadip R Banerjee et al. J Mol Med (Berl). 2003 Apr.

Abstract

Obesity and diabetes have reached epidemic proportions worldwide. The antidiabetic thiazolidinedione (TZD) drugs are insulin-sensitizing agents now widely used in the treatment of type 2 diabetes. TZDs are ligands for the nuclear hormone receptor peroxisome proliferator activated receptor gamma, which is a master regulator of adipogenesis and adipocyte metabolism. The molecular mechanisms by which TZDs improve insulin sensitivity have not been fully identified. Here we consider a novel secreted factor first identified as a TZD-suppressible gene in mouse adipocytes, called resistin, and discuss what is currently known about resistin regulation and function in mouse and human.

PubMed Disclaimer

References

    1. Diabet Med. 1999 Mar;16(3):179-92 - PubMed
    1. Nat Med. 2001 Aug;7(8):887-8 - PubMed
    1. Endocrinology. 2002 Jun;143(6):2445-8 - PubMed
    1. J Clin Invest. 2003 Jan;111(2):225-30 - PubMed
    1. Diabetes. 2002 Mar;51(3):863-6 - PubMed

Publication types

MeSH terms

LinkOut - more resources