doi: 10.1159/000231545.
Modulation of the release of SRS-A from bovine lung in vitro by several autonomic and autacoid agents
- PMID: 1270160
- DOI: 10.1159/000231545
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Modulation of the release of SRS-A from bovine lung in vitro by several autonomic and autacoid agents
Int Arch Allergy Appl Immunol.
1976.
Abstract
The immunological release of slow-reacting substance of anaphylaxis (SRS-A) from bovine lung is modulated by several autonomic and autacoid agents. Isoproterenol, a beta-adrenergic agonist, inhibited release of SRS-A, as did cyclic AMP. Phenylephrine also inhibited SRS-A release but through alpha-adrenergic mechanisms. This is in contrast to observations in human lung. Carbachol enhanced the release of bovine SRS-A. Histamine inhibited SRS-A release through the H2-receptor. Dopamine enhanced the release of SRS-A by means of a dopaminergic receptor. 5-HT did not significantly modulate SRS-A release.
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