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Comparative Study
. 1976 May;13(6):429-34.

Flutamide. Mechanism of action of a new nonsteroidal antiandrogen

G Sufrin, D S Coffey
  • PMID: 1270239
Comparative Study

Flutamide. Mechanism of action of a new nonsteroidal antiandrogen

G Sufrin et al. Invest Urol. 1976 May.

Abstract

Flutamide is a new nonsteroidal antiandrogen useful in the treatment of prostatic carcinoma. The mechanism of action of this compound was investigated using the sex accessory tissue of the male rat. Flutamide was found to block the action of both endogenous and exogenous testosterone and, in addition, to be a potent inhibitor of testosterone-stimulated prostatic DNA synthesis. Moreover, it is capable of inhibiting prostatic nuclear uptake of androgen. Electron microscopic observations further confirm the antiandrogenic properties of flutamide.

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