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. 2003 Apr;163(4):1549-53.
doi: 10.1093/genetics/163.4.1549.

Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein

Eric A Gaucher  1 , Michael M Miyamoto, Steven A Benner
Affiliations

Evolutionary, structural and biochemical evidence for a new interaction site of the leptin obesity protein

Eric A Gaucher et al. Genetics. 2003 Apr.

Abstract

The Leptin protein is central to the regulation of energy metabolism in mammals. By integrating evolutionary, structural, and biochemical information, a surface segment, outside of its known receptor contacts, is predicted as a second interaction site that may help to further define its roles in energy balance and its functional differences between humans and other mammals.

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