Leucine 2,3-aminomutase, an enzyme of leucine catabolism
- PMID: 1270414
Item in Clipboard
Leucine 2,3-aminomutase, an enzyme of leucine catabolism
J Biol Chem.
.
Free article
Abstract
The initial step in the fermentation of leucine to acetate, isobutyrate, and ammonia by Clostridium sporogenes is the B12 coenzyme-dependent conversion of alpha-leucine to beta-leucine (3-amino-4-methylpentanoate). The amino group migration reaction, catalyzed by leucine 2,3-aminomutase, is reversible and is inhibited by intrinsic factor. The enzyme activity has been found in several clostridia, in rat, sheep, rhesus, and African green monkey livers, and in human leukocytes.
Similar articles
-
Distribution of leucine 2,3-aminomutase activity in various organs of the rat and in subcellular organelles of rat liver.Biochem Biophys Res Commun. 1980 Sep 30;96(2):838-43. doi: 10.1016/0006-291x(80)91431-x. Biochem Biophys Res Commun. 1980. PMID: 7426015 No abstract available.
-
Beta-leucine and the beta-keto pathway of leucine metabolism.Adv Enzymol Relat Areas Mol Biol. 1986;58:173-89. doi: 10.1002/9780470123041.ch5. Adv Enzymol Relat Areas Mol Biol. 1986. PMID: 3521217 Review. No abstract available.
-
S-adenosylmethionine and the mechanism of hydrogen transfer in the lysine 2,3-aminomutase reaction.Cold Spring Harb Symp Quant Biol. 1987;52:571-7. doi: 10.1101/sqb.1987.052.01.065. Cold Spring Harb Symp Quant Biol. 1987. PMID: 3454278 No abstract available.
-
The role of S-adenosylmethionine in the lysine 2,3-aminomutase reaction.J Biol Chem. 1987 Nov 5;262(31):14859-62. J Biol Chem. 1987. PMID: 3117791
-
Lysine 2,3-aminomutase and the mechanism of the interconversion of lysine and beta-lysine.Adv Enzymol Relat Areas Mol Biol. 1993;66:1-39. doi: 10.1002/9780470123126.ch1. Adv Enzymol Relat Areas Mol Biol. 1993. PMID: 8430513 Review. No abstract available.
Cited by
-
Nitrous oxide has multiple deleterious effects on cobalamin metabolism and causes decreases in activities of both mammalian cobalamin-dependent enzymes in rats.J Clin Invest. 1981 May;67(5):1270-83. doi: 10.1172/jci110155. J Clin Invest. 1981. PMID: 6112240 Free PMC article.
-
The atu and liu clusters are involved in the catabolic pathways for acyclic monoterpenes and leucine in Pseudomonas aeruginosa.Appl Environ Microbiol. 2006 Mar;72(3):2070-9. doi: 10.1128/AEM.72.3.2070-2079.2006. Appl Environ Microbiol. 2006. PMID: 16517656 Free PMC article.
-
The mechanism of cobalamin-dependent rearrangements.Mol Cell Biochem. 1977 Apr 12;15(2):89-108. doi: 10.1007/BF01793331. Mol Cell Biochem. 1977. PMID: 302395
-
Intracellular binding of radioactive hydroxocobalamin to cobalamin-dependent apoenzymes in rat liver.Proc Natl Acad Sci U S A. 1977 Mar;74(3):916-20. doi: 10.1073/pnas.74.3.916. Proc Natl Acad Sci U S A. 1977. PMID: 15258 Free PMC article.
-
Cobalamins and cobalamin-dependent enzymes in Candida utilis.J Bacteriol. 1979 Dec;140(3):1013-6. doi: 10.1128/jb.140.3.1013-1016.1979. J Bacteriol. 1979. PMID: 574865 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
