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Case Reports
. 2003 Mar;42(3):277-80.
doi: 10.2169/internalmedicine.42.277.

Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2

Kotaro Mizutani  1 , Nobuyuki Oka, Susumu Kusunoki, Ryuji Kaji, Masutaro Kanda, Ichiro Akiguchi, Hiroshi Shibasaki
Affiliations
Free article
Case Reports

Amyotrophic lateral sclerosis with IgM antibody against gangliosides GM2 and GD2

Kotaro Mizutani et al. Intern Med. 2003 Mar.
Free article

Abstract

We report a case of amyotrophic lateral sclerosis (ALS) with IgM antibody against gangliosides GM2 and GD2. A 57-year-old woman presented with slowly progressive muscular weakness of the upper extremities and dysarthria. She fulfilled the clinical and electrophysiological criteria of ALS, and died from sudden suffocation about 3 years after the onset of illness. The patient's serum IgM antibody was shown to recognize the structure shared by GM2 and GD2. Since anti-GM2 antibodies have been implicated in motor neuropathy or motor neuron syndrome, this rare case might contribute to the understanding of the immunological aspects of ALS.

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