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. 1976 Mar;29(3):224-7.
doi: 10.1136/jcp.29.3.224.

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition

R K Chandra, S Chandra, O P Ghai

Chemotaxis, random mobility, and mobilization of polymorphonuclear leucocytes in malnutrition

R K Chandra et al. J Clin Pathol. 1976 Mar.

Abstract

Neutrophil mobilization following administration of Pseudomonas polysaccharide was significantly reduced in malnutrition, especially during infection. The random mobility of polymorphonuclear leucocytes (PMNs) was slightly decreased in undernutrition. Chemotactic migration of PMNs was depressed and correlated more with the presence of infection than with nutritional deficiency. It is possible that these abnormalities of PMN mobilization and mobility in malnourished individuals contribute to suboptimal amount, kinetics, and pattern of tissue inflammatory response to bacteraemic challenge.

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