doi: 10.1016/s0966-842x(03)00042-8.
A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors
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- PMID: 12706988
- DOI: 10.1016/s0966-842x(03)00042-8
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A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors
Trends Microbiol.
2003 Apr.
Abstract
Various bacterial protein toxins and effectors target Rho GTPases, which are eukaryotic regulators of signal transduction pathways. Many toxins inactivate these GTPases but some, such as the cytotoxic necrotizing factors (CNFs) from Escherichia coli, activate them by deamidation. Recent studies have provided exciting new clues to the functional consequences of the activation of Rho GTPases by CNFs and its effect on the host-pathogen interaction.
Comment in
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Response from Emmanuel Lemichez: A new turn in Rho GTPase activation by Escherichia coli cytotoxic necrotizing factors.Trends Microbiol. 2003 Apr;11(4):156. doi: 10.1016/s0966-842x(03)00043-x. Trends Microbiol. 2003. PMID: 12706989 No abstract available.
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