Review
doi: 10.1016/s0966-842x(03)00045-3.
Replication of human hepatitis delta virus: recent developments
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- PMID: 12706997
- DOI: 10.1016/s0966-842x(03)00045-3
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Review
Replication of human hepatitis delta virus: recent developments
Trends Microbiol.
2003 Apr.
Abstract
In a natural setting, hepatitis delta virus (HDV) is only found in patients that are also infected with hepatitis B virus (HBV). In hepatocytes infected with these two viruses, HDV RNA genomes are assembled using the envelope proteins of HBV. Since 1986, we have known that HDV has a small single-stranded RNA genome with a unique circular conformation that is replicated using a host RNA polymerase. These and other features make HDV and its replication unique, at least among agents that infect animals. This mini-review focuses on advances gained over the last 2-3 years, together with an evaluation of HDV questions that are either unsolved or not yet solved satisfactorily.
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