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. 2003 May;96(5):1409-1412.
doi: 10.1213/01.ANE.0000060451.82578.3A.

The effect of clonidine on gastrointestinal side effects associated with ultra-rapid opioid detoxification

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The effect of clonidine on gastrointestinal side effects associated with ultra-rapid opioid detoxification

Hong Ma et al. Anesth Analg. 2003 May.

Abstract

Clonidine, an alpha(2)-adrenergic agonist, is used to minimize withdrawal symptoms related to ultra-rapid opioid detoxification procedures. These preliminary data suggest that clonidine possesses dose-related antidiarrheal activity.

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References

    1. O’Conner PG, Kosten TR. Rapid and ultrarapid detoxification techniques. JAMA 1998; 279: 229–34.
    1. Ward J, Hall W, Mattick RP. Role of maintenance treatment in opioid dependence. Lancet 1999; 353: 221–6.
    1. Lorenzi P, Marsili M, Boncinelli S, et al. Searching for a general anaesthesia protocol for rapid detoxification from opioids. Eur J Anaesthesiol 1999; 16: 719–27.
    1. Spanagel R. Is there a pharmacological basis for therapy with rapid opioid detoxification? Lancet 1999; 354: 2017–8.
    1. Nakaki T, Chang PC, Tokunaga Y, et al. Alpha 2-adrenoceptors modulating diarrhea in morphine-dependent rats. J Pharm Pharmacol 1981; 33: 397–9.

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