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. 1976 May;31(3):271-4.
doi: 10.1093/geronj/31.3.271.

Experimental allergic encephalomyelitis in aged F344 rats

S Levine, R Sowinski

Experimental allergic encephalomyelitis in aged F344 rats

S Levine et al. J Gerontol. 1976 May.

Abstract

Experimental allergic encephalomyelitis (EAE) was produced in 2- to 24-mo.-old F344 rats by active immunization and by passive transfer of lymphoid cells (adoptive immunization) from young rats. With both methods, some 24-mo.-old rats had a reduced ability to develop this autoimmune disease. However, the immunological deficit was related to incidental serious diseases rather than to old age per se. The aged F344 rat is not a suitable model for comparing EAE to multiple sclerosis in man because the decreased incidence of multiple sclerosis after the age of 50 is not related to other serious illnesses.

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