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. 1976 May;116(5):1431-4.

The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex

E R Podack, W P Kolb, H J Muller-Eberhard
  • PMID: 1270802

The C5b-9 complex: subunit composition of the classical and alternative pathway-generated complex

E R Podack et al. J Immunol. 1976 May.

Abstract

The membrane attack complex of complement (C5b-9) is identical in composition regardless of which pathway of activation was instrumental in its formation. Band V protein was consistently a subunit of the soluble complex. Since band V protein is not required for complement-dependent cytolysis, it probably represents a membrane site equivalent in serum of the nascent C5b-9 complex.

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