The ups and downs of Gs- to Gi-protein switching
- PMID: 12711616
- PMCID: PMC1573788
- DOI: 10.1038/sj.bjp.0705192
The ups and downs of Gs- to Gi-protein switching
Comment on
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Cardiac-specific overexpression of human beta2 adrenoceptors in mice exposes coupling to both Gs and Gi proteins.Br J Pharmacol. 2003 Apr;138(7):1358-66. doi: 10.1038/sj.bjp.0705191. Br J Pharmacol. 2003. PMID: 12711637 Free PMC article.
References
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- BOND R.A., LEFF P., JOHNSON T.D., MILANO C.A., ROCKMAN H.A., MCMINN T.R., APPARSUNDARAM S., HYEK M.F., KENAKIN T.P., ALLEN L.F., LEFKOWITZ R.J. Physiological effects of inverse agonists in transgenic mice with myocardial overexpression of the beta 2-adrenoceptor. Nature. 1995;374:272–276. - PubMed
-
- DAAKA Y., LUTTRELL L.M., LEFKOWITZ R.J. Switching of the coupling of the beta 2-adrenergic receptor to different G-proteins by protein kinase A. Nature. 1997;390:88–91. - PubMed
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- FRIEDMAN J., BABU B., CLARK R.B. β2-adrenergic receptor lacking the cyclic AMP-dependent protein kinase consensus sites fully activates extracellular signal-regulated kinase 1/2 in human embryonic kidney 293 cells: lack of evidence for GS/Gi switching. Mol. Pharmacol. 2002;62:1094–1102. - PubMed
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- KILTS J.D., AKAZAWA T., RICHARDSON M.D., KWATRA M.M. Age increases cardiac Gαi2 expression, resulting in enhanced coupling to G protein-coupled receptors. J. Biol. Chem. 2002;277:31257–31262. - PubMed
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